Search on: PORE FORMING CYTOTOXIC PROTEINS 
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Descriptor English:   Pore Forming Cytotoxic Proteins 
Descriptor Spanish:   Proteínas Citotóxicas Formadoras de Poros 
Descriptor Portuguese:   Proteínas Citotóxicas Formadoras de Poros 
Tree Number:   D12.776.543.695
Definition English:   Proteins secreted from an organism which form membrane-spanning pores in target cells to destroy them. This is in contrast to PORINS and MEMBRANE TRANSPORT PROTEINS that function within the synthesizing organism and COMPLEMENT immune proteins. These pore forming cytotoxic proteins are a form of primitive cellular defense which are also found in human LYMPHOCYTES. 
See Related English:   Porins
 
History Note English:   2007 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   52332 
Unique Identifier:   D052899 

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